NFL Week 12 Sunday Slate Spread Picks NFL Betting Odds

Thanksgiving has come and gone and so has the inaugural NFL Black Friday game, but there’s still a ton of Week 12 action to come on Sunday. We’re going down the line of the entire Sunday slate and giving you the inside track in a week that has 10 of 11 games offering spreads of four points or fewer. We won’t be looking at moneyline favorites, but instead we’ll be handicapping the spread for each game based on the best odds from the top NFL betting sites.

NFL Week 12 Sunday Slate Betting Odds - Sunday, November 26th

All odds provided by Sports Interaction.

Atlanta Falcons vs. New Orleans Saints - 1PM

This battle for the top spot in the worst division in football, the NFC South, could not have come at more inopportune time for the Atlanta Falcons. They’ve lost three in a row and they still don’t have a firm grasp on who’s leading their team from under center. They’ve also been awful at home, going 1-4 ATS this season, so we’re taking the Saints to cover a -1.5 spread.

Cincinnati Bengals vs. Pittsburgh Steelers - 1PM

Mike Tomlin loves going up against rookie quarterbacks, and while Jake Browning isn’t a rookie, he might as well be, as this will be his first NFL start. The Steelers have been getting the run game going recently, which should help them cover a -2.5 spread against the second-worst run defense in the NFL.

Tennessee Titans vs. Carolina Panthers - 1PM

Expect this one to be a tough game to watch, as two teams vying for the top pick next year go head to head. Bryce Young and the Panthers have given us no reason to trust in them, and while the Titans haven’t been much better, Carolina’s bottom 10 run defense should allow King Derrick Henry to help his team cover a -3.5 spread at home.

Indianapolis Colts vs. Tampa Bay Buccaneers - 1PM

The Indianapolis Colts have kind of been skating by recently, staying on the playoff bubble without too much noise surrounding them. However, the Bucs know they need this game to stay in the NFC South race, and with their 5-0 ATS record on the road this year, we like Tampa Bay to cover a +2.5 spread. 

Houston Texans vs. Jacksonville Jaguars - 1PM

Another battle that could decide a divisional race, the Jaguars are in the driver’s seat, but maybe not for much longer. C.J. Stroud will be able to slice and dice the fourth-worst pass defense in the NFL and the Texans will cover a +1.5 underdog spread.

Denver Broncos vs. Cleveland Browns - 4:05PM

Whatever you bet on with this game, make sure it’s the under. In terms of spread, the Cleveland Browns defense has been dominant enough to make us believe that they’ll have Russell Wilson and his offensive line, which has given up the seventh-most sacks, in hell. We like Myles Garrett and the Browns to cover a +1.5 spread.

Arizona Cardinals vs. Los Angeles Rams - 4:05PM

Kyler Murray has been excellent since he made his return, and while they’re likely to be fighting for next year’s top pick as the season runs down, we expect them to grab another win or two. This could be one of those days, so we’re taking Arizona to cover a +2.5 spread at home.

Las Vegas Raiders vs. Kansas City Chiefs - 4:25PM

The only spread on the Sunday slate above four points, the Chiefs have not looked their best recently. Well, their offense hasn’t. Their defense has been excellent, and after a loss we expect the whole team to bounce back big time, so we like the Chiefs to cover a larger-than-we’d-like -10.0 spread.

Philadelphia Eagles vs. Buffalo Bills - 4:25PM

The Philadelphia Eagles are coming off of arguably their biggest win this year. They’ll have all the confidence in the world coming into this one at Lincoln Financial, and Buffalo has been terrible on the road, putting up a 1-3 ATS record away from home. Take Philly by -3.0 here.

Los Angeles Chargers vs. Baltimore Ravens - 1PM

It’s do or die time for the Los Angeles Chargers. The Baltimore Ravens are clearly the superior team here, but with L.A.’s offense, they’re never out of a game. We expect the Ravens to win, but not by much, so we’ve got the Chargers to cover a +3.5 home spread.