Champions League Leg 2: Atletico vs Real Madrid Predictions, Team News & Betting Preview

Quinn Allen
By: Quinn Allen
12 Mar 25
Soccer
Photo courtesy of Free Malaysia Today

Photo courtesy of Free Malaysia Today

The title-holders will be looking to move one step closer to another Champions League title on Wednesday, March 12 as Real Madrid visits Atletico Madrid in the second leg of this Round of 16 tie. The kick-off is scheduled for 4 PM ET. Los Blancos ran out 2-1 winners in the reverse fixture last week courtesy of goals from Brahim Diaz and Rodrygo. This should be another entertaining clash, with a spot in the quarterfinals on the line. Below, we’ll provide the Atletico vs Real Madrid odds, analysis, team news, and match prediction.

Highlights

  • Real Madrid and Atletico Madrid meet on Wednesday
  • Los Blancos won the first leg 2-1 last week
  • Keep reading for the match preview

Odds provided by Sports Interaction.

Atletico vs Real Madrid Odds

As you can see, Atleti is a slim +125 favorite on home soil. The hosts played to a 1-1 draw with Real earlier this season in La Liga action at home. Three of the last four meetings have cashed the Under in goals, all finishing 1-1 before Los Blancos’ 2-1 victory a week ago.

Atletico vs Real Madrid Analysis

Diego Simeone’s side is having a solid campaign across the board, sitting in third place in Spain and just one point out of top spot while also impressing in the UCL. They finished in fifth in the expanded group stage and earned an automatic berth to the Round of 16.

Julian Alvarez has been a breath of fresh air for Atleti since arriving from Manchester City, leading the line up top. The Argentine has bagged 22 goals across all competitions, including seven in Europe’s most prized competition. Antoine Griezmann has also come alive in the UCL with six goals. Alvarez netted Atleti’s lone goal in the first leg and will be key once again here.

Los Blancos haven’t had it easy so far in the Champions League, but by no surprise, they’ve lived up to expectations. The 15-time winners had to advance through the Play-Off after an underwhelming group campaign, beating Man City across two legs.

Carlo Ancelotti’s squad then produced the goods at home last Tuesday. Rodrygo opened the scoring within four minutes before Alvarez equalized prior to halftime. However, Diaz played hero in the second half with a stunner, giving Real the advantage heading into Wednesday’s decisive second leg, despite being a very slim underdog at soccer betting sites.

Atletico vs Real Madrid Team News

Atleti are sitting pretty from a health standpoint ahead of this fixture. Koke is their only notable absence as he’s sidelined due to a leg injury. Other than that, Simeone has no concerns and will be rolling out his best starting XI in the hopes of overcoming this deficit against his bitter rivals.

As for Los Blancos, they have a few injury concerns. Dani Carvajal, Dani Ceballos, and Eder Militao remain out. Antonio Rudiger and Thibaut Courtois didn’t feature over the weekend in a crucial 2-1 victory over Rayo Vallecano, but both should be back in the mix at the Estadio Civitas Metropolitano.

Atletico vs Real Madrid Predictions

While Atleti is unbeaten in their last five cup meetings with Real Madrid including four wins, they’ve never beaten their foes in a Champions League tie. Los Blancos are fresh off a huge win over Vallecano and have a full-strength squad here.

I expect this to be a cagey affair as it usually is when these two sides go to battle, but the holders will come out victorious. Lock in the moneyline as it offers immense value. Also, both teams to score at -190 is worth a look as well.

Pick: Real Madrid moneyline (+165), Both teams to score (-190)

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Quinn Allen is a seasoned sports journalist from Vancouver, Canada. Quinn is a full-time senior editor for ClutchPoints where he specializes in baseball, soccer, basketball, and football. Quinn has been working in the industry for five years and brings a unique outlook to sports journalism, having played high-level soccer and baseball growing up. Quinn resides in Kelowna, Canada, and enjoys playing soccer and going to the gym.